Monsanto and Glyphosate

Glyphosate is the active ingredient in the popular herbicide, Roundup. Glyphosate toxicity is a big deal and what you don’t know just might kill anti agingyou! Many people routinely spray their lawns with this chemical totally  unaware of the toxicity.

In the United States, farmers are applying ever increasing amounts to their crops before harvest. According the the World Health Organization, glyphosate is now declared a probable carcinogen” which means it may cause cancer.  The industry still asserts that it is totally safe for humans.  One only needs to look at the data to know that is not true.

Ignorance may be bliss but we may be on the verge of one of the most toxic man made environmental disasters in history.  Unfortunately this chemical is persistent in both the environment and the human body and it is not easy to clean up.

France’s highest court found Monsanto guilty of lying as far back as 2008 about the toxicity of it’s popular weedkiller, Roundup. “The court confirmed an earlier judgment that Monsanto had falsely advertised its herbicide as “biodegradable” and claimed it “left the soil clean”

According to an Article in Nature published March 24, 2015:

Glyphosate is the world’s most widely produced herbicide, by volume. It is used extensively in agriculture and is also found in garden products in many countries. The chemical is an ingredient in Monsanto’s weedkiller product Roundup.  Glyphosate has become more popular with the increasing market share of crops that are genetically engineered to be tolerant to the herbicide.

California recently became the first state to issue plans to list glyphosate as a chemical known to cause cancer according to EcoWatch.  This is big news and we need to pay attention.  The use of glyphosate has nearly doubled from 95 million pounds in 2001 to nearly 185 million pounds in 2007.   According to the latest  released report from the EPA and who knows how much it’s increased from  2007 until 2016, 9 years later!

Dr. Anthony Samsel and Dr. Stephanie Seneff state in their recent article published August 2015:

Glyphosate has a large number of tumorigenic [cancer-causing] effects on biological systems.  Including direct damage to DNA in sensitive cells, disruption of glycine homeostasis, succinate dehydrogenase inhibition, chelation of [minerals such as] manganese, modification to more carcinogenic molecules, such as N-nitrosoglyphosate and glyoxylate, disruption of fructose metabolism, etc…

Sadly epidemiological evidence supports a strong correlation between the dramatic rise in use of glyphosate on crops.   And the multitude of cancers reaching epidemic proportions, such as breast, pancreatic, kidney, thyroid, bladder, and liver cancers.

In perhaps the most ironic twist of all, glyphosate has proven highly toxic to the basic phase one detoxification of the liver, the cytochrome pathways.

I find it incredibly alarming that one of the most toxic chemicals known to mankind also exerts its influence by impairing human detoxification.

Did you get that!? A toxic chemical that makes is harder to detox… what nonsense!

Here is an excerpt from  Entropy 2013, Glyphosate’s Suppression of Cytochrome P450 enzymes and amino acid biosynthesis by the gut microbe:

Glyphosate’s inhibition of cytochrome P450 (CYP) enzymes is an overlooked component of its toxicity to mammals. CYP enzymes play crucial roles in biology, one of which is to detoxify xenobiotics. Thus, glyphosate enhances the damaging effects of other food borne chemical residues and environmental toxins. Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body.

Glyphosate may trigger autoimmunity, such as celiac disease by the following mechanisms:

  • Spraying of wheat before harvest with glyphosate, a common practice in North America allows for a large exposure to glyphosate in wheat.
  • Wheat may be the most common ingredient in processed foods.
  • Glyphosate also damages the microvilli in gut reducing ability to absorb vitamins and minerals
  • Wheat contains gliadin, which is difficult for genetically susceptible individuals to break down.
  • Glyphosate may attach to the gliadin as a consequence of a chemical interaction between the chemical make it even harder to break down this large protein molecule.
  • It may not be recognized by the body or able to be broken down, making even more likely to induce an immunological response in susceptible individuals, contributing to development of celiac disease

In addition to celiac disease, researchers now believe that glyphosate may be linked to the following diseases:

  1. Autism
  2. Autoimmune diseases
  3. Cancer
  4. Parkinson’s
  5. Alzheimer’s disease
  6. Inflammatory bowel diseases (Crohn’s and Ulcerative Colitis)
  7. Cardiovascular disease
  8. Depression
  9. Infertility

 

Glyphosate is also toxic to our gut microbiome

Glyphosate is toxic to many of our beneficial gut microbes. It may preferentially kill off species, like lactobacillus while leaving potential pathogens, like clostridia to run wild. Glyphosate also chelates essential minerals, such as manganese, iron, cobalt, molybdenum, and copper so that the gut microbes do not have access to them. This leads to chronic inflammatory states in the gut as well as increased intestinal permeability, a mechanism at the core of many chronic illnesses, including inflammatory bowel disease, depression, and autoimmunity.

If you are eating processed food, you are eating glyphosate…

Residues of glyphosate are commonly found in the most common foods in the American Diet, including

  1. Corn
  2. Soy
  3. Sugar Beets (sugar)
  4. Canola
  5. Cotton (not food but in clothing, sanitary napkins and many products we use daily)

Nearly one billion pounds of glyphosate are doused on both conventional and genetically modified crops worldwide each year but GMO crops receive the largest amounts. Processed foods undoubtable expose you to this toxic contamination, courtesy of wheat, corn, soy and the vegetable oil used. And the meats from conventionally raised animals in confined feed lots are given fed that most likely contains glyphosate-laden corn and soy.

 

Ok, so what can I do about it?!

The most important thing to realize is that you cannot wash glyphosate off food since it is incorporated into each cell of plant.

Here are some tips to keep your diet free of glyphosate:

  • Only way to 100% eliminate from your diet is to avoid conventionally grown and processed foods
  • Glyphosate accumulates in animal tissues, so make sure your meat was not fed GMO grains and your butter and dairy is organic
  • Switch over to a 100% organic diet
  • Take activated charcoal or rice bran powder in aiding elimination of organophosphates and glyphosate after exposure
  • Maintain adequate mineral status by taking a multi-mineral supplement that includes trace minerals
  • Support glutathione production with N-acetylcysteine, glycine and glutamine or oral liposomal glutathione
  • Support phase 1 and phase 2 liver detoxification by avoiding alcohol and taking liver support, like silymarin, lipoid acid
  • It is much harder to reverse damage once it’s done, so best to avoid glyphosate from the start—especially in children!

So go to it…  It’s worth every penny to grow your own food and/or buy organic and begin to detox your body of this dangerous chemical!

anti agingantiaging

 

Pomegranate’s

Do You or Someone You Love Suffer From Atherosclerosis,
Prostate or Breast Cancer?

Let’s Talk Pomegranate’s

Pomegranates are not a new fruit juice—but the human clinical studies are. Based on these findings, it may now be possible for people with severe atherosclerosis to reverse it. Those who have relatively healthy arteries to begin with might be able to significantly delay or prevent the onset of atherosclerosis.

 Pomegranate’sIf all this fruit did was protect our inner arterial wall (the endothelium), then it may be the most important agent that aging humans could ingest. What has scientists most excited, however, is a new human study showing that this fruit dramatically slowed the progression of prostate cancer in those who already failed conventional treatment.

These expensive human studies were conducted based on an abundance of test tube and live animal data indicating this fruit will prevent and treat vascular disease and prostate cancer. These same test tube studies show that this fruit will also be effective against breast cancer.

Prescription medications can slow the progress of atherosclerosis, but they rarely reverse it. To significantly reduce human mortality, a way to stop age-associated arterial deterioration must be found. As you will soon read, this may have been achieved in humans with a fruit that functions via mechanisms quite different from conventional drugs.

Government agencies caution consumers to be leery of health products that promise “miraculous” results. The reason for these warnings is that unscrupulous companies continue to make outlandish claims with little scientific substantiation to back them.

While it may be too early to promise “miraculous benefits” in response to ingesting this fruit, the human studies supporting it are miraculous from a scientific standpoint.

Reversing Atherosclerosis

While certain drugs, nutrients, and hormones can slow the progression of atherosclerosis, very little has ever been shown to reverse existing artery disease.

One reason it is so difficult to reverse atherosclerosis is that arterial disease is primarily caused by aging itself (via the destructive process known as endothelial dysfunction). This means that a person with atherosclerosis has to first stop the artery-damaging process and then reverse the damage and occlusion to the arterial wall that has accumulated over a lifetime.

Atherosclerosis can be measured in humans by conducting an ultrasound test of the carotid arteries in their necks. An ultrasound provides a specific reading of the narrowing (or blockage) that has occurred by measuring the thickness of the inner and middle walls of the carotid artery. This is known technically as an intima-media thickness test (IMT).

A controlled human study was conducted involving patients with severe carotid artery narrowing (stenosis).  One group received conventional drugs only (statins and anti-hypertensives), while the other group received pomegranate juice plus the same drugs. The findings observed in the pomegranate group were unprecedented.

After one year, the group receiving the drugs, but not pomegranate showed a significant 9% increase in intima-media thickness. In contrast, the group receiving the pomegranate juice plus drugs showed a reduction in carotid intima-media thickness as follows:

  • After three months: 13%
  • After six months: 22%
  • After nine months: 26%Pomegranate’s
  • After one year: 35%

Carotid artery blood flow improved in the pomegranate plus drugs group as follows:

  • After three months: 16%
  • After six months: 20%
  • After nine months: 31%
  • After one year: 44%

Blood samples were collected before and during treatment with pomegranate in these patients with narrowed carotid arteries. The changes shown in the box above help explain why pomegranate so effectively reversed carotid intima-media thickness.

Another blood test used in this study measured paraoxonase-1, an antioxidant enzyme produced in the body. Paraoxonase-1 is associated with beneficial HDL and is believed to protect against the oxidation of LDL. Low levels of paraoxonase-1 predict increased severity of coronary artery disease. In patients administered pomegranate, the paraoxonase-1 levels increased by 83% after only one year!

After one year of taking pomegranate, there was also a 21% decrease in systolic blood pressure and more than 50% reduction in measured free radical activity in the carotid atherosclerotic plaque.

The scientists attributed the regression in carotid atherosclerotic lesion size in the pomegranate group to significantly reduced oxidative stress in both blood and atherosclerotic plaques, along with modestly lower blood pressure (beyond that of the anti-hypertensive drugs that were prescribed).

LDL basal oxidative state Reduced by 90%

LDL susceptibility to copper-induced oxidation Reduced by 59%

Total antioxidant status Improved by 130%

What Makes Pomegranate So Special?

Numerous studies show that pomegranate is nature’s most powerful antioxidant. The remarkable effect of pomegranate against various human disorders, however, makes one question whether there is more to this fruit than just its free radical suppressing effects.

One answer to this question lie in the fact that pomegranate is absorbed into the bloodstream far more efficiently than other fruit extracts. One study showed a pomegranate extract to be 95% absorbed, which is far greater than any polyphenol-containing fruit extract of its kind.

Pomegranate’sPomegranate also suppresses a dangerous inflammatory cytokine called interleukin-1 beta. As humans age, increases in interleukin-1 beta wreak havoc in tissues throughout the body. Pomegranate has been shown to alleviate a host of inflammatory-related disorders. As many of you already know, chronic inflammation can exacerbate atherosclerosis and cancer.Another reason that pomegranate has displayed such incredible clinical findings is that it contains a unique polyphenol group called punicalagins. Not only do punicalagins display potent antioxidant effects, but they also interfere with growth factors needed by cancer cells to propagate. By down-regulating these pathological growth factors, punicalagins have been shown to induce the destruction (apoptosis) of common cancer cells.

Where to Obtain Pomegranate

Pomegranate juice is now found in supermarkets and every health food store.

The first complaint most people have about pomegranate juice is its high cost. One concern expressed by health conscious people is, like all fruit juices, pomegranate juice is very high in sugar.

The high calorie content of sugar-laden beverages is a concern for anyone seeking to maintain a healthy body weight and control their sugar intake.  Adding extra calories also accelerates various aging processes, which would negate some of the beneficial effects of the polyphenols naturally contained in pomegranate.

The good news is that proprietary extraction methods have been developed to enable consumers to obtain pomegranate’s active constituents without having to ingest the sugar calories or pay the high prices charged for pomegranate juices.

 

An Anti Aging Pill

An anti-aging startup hopes to elude the U.S. Food and Drug Administration and death simultaneously.

The company, Elysium Health, says it will be turning chemicals that lengthen the lives of mice and worms
in the laboratory into over-the-counteranti aging pill vitamin pills that humans can swallow to combat aging.

The startup is being founded by Leonard Guarente, an MIT biologist who is 62 and who’s convinced that the process of aging can be slowed by tweaking the body’s metabolism.

Guarente says, the problem is that it’s nearly impossible to prove, in any reasonable time frame, that drugs that extend the lifespan of animals can do the same in people; such an experiment could take decades. That’s why Guarente says he decided to take the unconventional route of packaging cutting-edge lab research as so-called nutraceuticals.  Nutraceuticals do not require clinical trials or approval by the FDA.

This means there’s no guarantee that Elysium’s first product, a blue pill called Basis, which is going on sale this week, will actually keep you young. The Basis product contains a chemical precursor to nicotinamide adenine dinucleotide, or NAD, a compound that cells use to carry out metabolic reactions like releasing energy from glucose. The compound is believed to cause some effects similar to a calorie reduction diet—a proven way to make a mouse live longer.

Elysium’s approach to the anti-aging market represents a change of strategy for Guarente. He was previously involved with Sirtris Pharmaceuticals, a high-profile biotechnology startup that studied resveratrol, an anti-aging compound found in red wine that it hoped would help patients with diabetes. That company was bought by drug giant GlaxoSmithKline, but early trials failed to pan out.

This time, Guarente says, the idea is to market anti-aging molecules as a dietary supplement and follow up with clients over time with surveys and post-marketing studies. Guarente is founding the company along with Eric Marcotulli, a former venture capitalist and technology executive who will be CEO, and Dan Alminana, chief operating officer.

The company says it will follow strict pharmaceutical-quality production standards and make the supplements available solely through its website, for $60 for a 30-day supply or $50 per month with an ongoing subscription.

“You have high-end prescription drugs up here, which are expensive,” says Guarente, gesturing upward. “And you have the nutraceuticals down there, which are a pig in a poke—you don’t know what you’re getting and you don’t know a lot about the science behind them. There’s this vast space in between that could be filled in a way that’s useful for health maintenance.”

An anti-aging pill with an ivory-tower pedigree could prove profitable. The $30 billion supplements market is growing at about 7 percent a year overall, Alminana says, and at twice that rate for online sales.

Elysium declined to name its investors, but it has some high-level endorsements. Its board includes Daniel Fabricant, former director of the FDA’s division of dietary supplements and now CEO of the Natural Products Association, a trade association. The company also has five Nobel Prize winners advising it including neuroscientist Eric Kandel, biologist Thomas Südhof, origin-of-life theorist Jack Szostak, and the 2013 laureate in chemistry Martin Karplus.

Karplus, now an emeritus professor at Harvard, said in a telephone interview that he was turning 85 this year and had asked the company to send him a supply of Basis as soon as it’s available. “I want to remind myself whether I really want to take it or not,” says Karplus.

Scientists have shown they can reliably extend the life of laboratory mice by feeding them less, a process known as “caloric restriction.” That process seems to be mediated by biological molecules called sirtuins. NAD is important because it’s a chemical that sirtuins need to do their work and is also involved in other aspects of a cell’s metabolism. In worms, mice, and people, NAD levels fall with age, says Guarente, so the idea is to increase levels of the molecule.

“NAD replacement is one of the most exciting things happening in the biology of aging,” says Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine in New York, who has coauthored scientific papers with Guarente but is not involved in Elysium. “The frustration in our field is that we have shown we can target aging, but the FDA does not [recognize it] as an indication.”

Other experts said while NAD may decline with age, there is limited evidence that aging can be affected by restoring or increasing NAD levels. “There is enough evidence to be excited, but not completely compelling evidence,” said Brian K. Kennedy, CEO of the California-based Buck Institute for Research on Aging.

Guarente says Elysium’s pill includes a precursor to NAD, called nicotinamide riboside, which the body can transform into NAD and put to use. In addition, the pill contains pterostilbene, an antioxidant that Guarente says stimulates sirtuins in a different way. Both ingredients can already be found in specialty vitamins.  “We expect a synergistic effect [from] combining them,” he says.

Guarente says Elysium plans to gradually add to its product line with other compounds shown in academic labs to extend the healthy lifespan of worms, mice, or other animals. The company will do preliminary testing to make sure the products are not toxic but will not follow the arduous FDA approval process. Vitamins and supplements can be sold over the counter as long as they contain ingredients known to be safe and don’t make overly specific health claims.

Marcotulli says the company has some anecdotal evidence that Elysium’s pills make a difference. “For older demographics, we’ve heard really interesting feedback related to levels of energy. It’s very, very useful and restorative,” he says. And he takes the pills himself. “When I don’t have a supply, I feel actually fuzzy,” he said. “It’s become a staple of my routine.”

Guarente also says he takes Basis every day, along with 250 mg of resveratrol, the red-wine compound. Guarente also exercises—though not, he says, as often as he should.

He says it doesn’t trouble him that he sees no obvious benefits yet from his supplement regimen. Too many studies in the anti-aging field, he says, are too short-term to show real benefits. Or else they study people who are already unhealthy. “I think that’s the way it would be if something is really acting to slow your progression into decrepitude—you’re not going to notice that,” Guarente says.